FEATURES OF THE TOXIC EFFECT OF SOME MACROMYCETE FUNGI OF THE BIRSKY DISTRICT OF THE REPUBLIC OF BASHKORTOSTAN
Abstract
The article provides an overview of the most common poisonous mushrooms of the Republic of Bashkortostan, characterizes their toxins and toxin –induced syndromes. The toxicity of poisonous fungi (Amanita phalloides (Vaill. ex Fr.) Link, Amanita muscaria (L. ex Fr.) Hook., Hygrophoropsis aurantiaca (Wulfen) Maire) collected on the territory of the Birsky district of the Republic of Bashkortostan during the growing season of 2020 has been studied. To control the experiment, we took the fruit bodies of edible mushroom species Paxillus atromentosus (Batsch: Fr.) Fr. and Suillus grevillei (Klotzsch) Singer. When studying the toxicity of these types of fungi, the test object was a test culture of Paramecium caudatum. It has been shown that fungi containing toxic peptides that determine the phalloid syndrome exhibit a strong toxic effect in relation to the culture of Paramecium caudatum, toxins causing cholinergic syndrome are characterized by a toxic effect in relation to the test culture. Toxins that cause atropine and hallucinetory syndrome are characterized by a slightly toxic effect in relation to the test culture. The results of the conducted studies can be used to make an etiological diagnosis in toxicology for poisoning with poisonous mushrooms.
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References
Mirkin B.M. Griby Bashkirii [Mushrooms of Bashkiria] / B.M. Mirkin, L.G. Naumova – Ufa: Bashkirskoe knizhnoe publishing house, 1979. – 96 p. [in Russian]
Habibullina A.M. Nekotorye rezul'taty issledovanij gribov v YUzhno –Ural'skom zapovednike [Some results of mushroom research in the South Ural Nature Reserve] / A.M. Habibullina // Lesa Bashkortostana: sovremennoe sostoyanie i perspektivy. – Master. Nauchno –prakticheskaya konferenciya [Forests of Bashkortostan: current state and prospects. – Master. Scientific and practical conference]. Ufa – 1997. P. 227 –228. [in Russian]
Kucherova, S. V. Yadovitye griby [Poisonous mushrooms] / S. V. Kucherova, M.A. Il'gamov // Bashkirskaya enciklopediya: V 7 tomah [Bashkir Encyclopedia: In 7 volumes / Editor –in –chief: M.A. Ilgamov]. – Ufa: Bashkirskaya enciklopediya [Bashkir Encyclopedia], 2011. – 436 p. [in Russian]
Kucherova S.V. Griby Bashkortostana [Mushrooms of Bashkortostan] / S.V. Kucherova. – Ufa.: Slovo Publishing House, 2005. – 128 p. [in Russian]
Petrova M.V. Resursnoe znachenie gribov –makromicetov Gafurijskogo rajona Respubliki Bashkortostan [Resource value of fungi –macromycetes of the Gafuriysky district of the Republic of Bashkortostan] / M.V. Petrova // Global Challenges – Scientific Solutions III Proceedings conference. Nitra, Slovakia: IP "Evrazijskij centr innovacionnogo razvitiya DARA", 2021. P. 65 –69. [in Russian]
Griby Bashkirii. ch.1. [Mushrooms of Bashkiria. Part 1.]. – Ufa: Publishing House Bashkirskogo obkoma KPSS, 1985. – 48 p. [in Russian]
Informaciya o rezul'tatah toksikologicheskogo monitoringa v Respublike Bashkortostan v 2019 –2020 godah [Information on the results of toxicological monitoring in the Republic of Bashkortostan in 2019 –2020] [Electronic resource] / URL: http://02.rospotrebnadzor.ru/content/193/40022/ (accessed: 15.10.21) [in Russian]
Landi N. Purification, characterization and cytotoxicity assessment of ageritin: the first ribotoxin from the basidiomycete mushroom Agrocybe aegerita / N. Landi, S. Pacifico, S. Ragucci et al. // Biochim. Biophys. Act. Gen. Subj. – 2017. – V. 1861. № 5.– Pt A. – P. 1113–1121.
Kretz O. Characterization of bolesatine, a toxic protein from the mushroom Boletus satanas Lenz and it’s effects on kidney cells / O. Kretz, E.E. Creppy, G. Dirheimer. // Toxicology. – 1991. – V. 66. № 2. – P. 213–224.
White J. Mushroom poisoning: a proposed new clinical classification / J. White, S.A. Weinstein, L. De Haro et al. // Toxicon. – 2019. – V. 157. – P. 53 –65.
Nikitina O. A. Opredelenie toksichnosti nekotoryh yadovityh gribov s pomoshch'yu paramecijnogo testa [Determination of the toxicity of some poisonous fungi using a paramecium test] / O. A. Nikitina // Uspekhi medicinskoj mikologii [Successes of medical mycology]. – 2004. – Vol. 3. – P. 287 [in Russian]
Luzhnikov E.A. Ostrye otravleniya [Acute poisoning] / E.A. Luzhnikov, L.G. Kostomarova – M.: Medicina, 2000. – 382 p. [in Russian]
Musselius S.G. Otravlenie gribami [Mushroom poisoning] / S.G. Musselius, A.A. Ryk – M.: Miklosh, 2002. – 324 p. [in Russian]
Gavryuchenkov D. V. Massovye otravleniya gribami [Mass mushroom poisoning] / D. V. Gavryuchenkov, E. Yu. Lemeshchenko // Medicinskaya sestra [A nurse]. – 2015. – № 2. – P. 48–49. [in Russian]
Yilmaz I. A case study: what doses of Amanita phalloides and amatoxins are lethal to humans? / I. Yilmaz, F. Ermis, I. Akata I. // Wild. Environ. Med. 2015. – V. 26. № 4. – P. 491–496.
Stasyk T. A new highly toxic protein isolated from the death cap Amanita phalloides is an L –amino acid oxidase / T. Stasyk, M. Lutsik –Kordovsky, C. Wernstedt et al. // FEBS J. 2010. – V. 277. № 5. – P. 1260–1269.
Hovpachev A.A. Sovremennye predstavleniya o toksinah vysshih gribov: ciklicheskie peptidy [Modern ideas about toxins of higher fungi: cyclic peptides] / A. A. Hovpachev, V. A. Basharin, S. V. Chepur et al. // Uspekhi sovremennoj biologii [Successes of modern biology]. – 2020. – Vol. 140. № 6. – P. 584 –600. DOI 10.31857/S0042132420060058. [in Russian]
Zheleva A., Tolekova A., Zhelev M. Free radical reactions might contribute to severe alpha –amanitin hepatotoxicity – A hypothesis // Med. Hypoth. – 2007. – V. 69. № 2. – P. 361–367.
Gurevich L.S. Izuchenie toksinov Amanita verna (Bull.: Fr.) Vitt. i Amanita virosa (Fr.) Bertill. metodom vysokoeffektivnoj zhidkostnoj hromatografii [Study of toxins Amanita verna (Bull.: Fr.) Vitt. and Amanita virosa (Fr.) Bertill. by the method of high –performance liquid chromatography] / L.S. Gurevich., I.K. Zhurkovich, E.L. Nezdojminogo // Mikol. fitopatol. – 1995. – Vol. 29. № 3. – P. 32–39 [in Russian]
Vishnevskij M. V. Samye rasprostranennye s"edobnye griby [The most common edible mushrooms] / M.V. Vishnevskij – M., 2014. – 35 p. [in Russian]
Polenov A. V. Griby. S"edobnye i nes"edobnye [Mushrooms. Edible and inedible] / A.V. Polenov – SPb., 2013. – 7 p. [in Russian]
Sergeeva M. N. Griby. Karmannyj atlas –opredelitel' [Mushrooms. Pocket Atlas –determinant] / M.N. Sergeeva – M., 2014. – 63 p. [in Russian]
Harding P. How to Identify Edible Mushrooms / P. Harding, T. Lyon, G. Tomblin – London New York, 2007. – P. 177.
Marley G. A. Chanterelle Dreams, Amanita Nightmares / G.A. Marley – White River Junction, VT, 2010. – P. 97.
Avtorskoe svidetel'stvo № 130160 A1 SSSR, MPK C12Q 1/02. Sposob opredeleniya toksichnosti gribov: № 642904 [Copyright certificate No. 130160 A1 USSR, IPC C12Q 1/02. Method for determining the toxicity of fungi: No. 642904]: application 03.11.1959: publ. 10.10.1960 / I. I. Ochkina, N. A. Spesivceva. [in Russian]