Polymorphism of Folate Cycle Genes (MTHFR, MTR and MTRR) in Vegetable Farm Workers of Different Ethnicities
Table 1 - Comparative analysis of genotype frequencies in polymorphic variants of folate cycle genes in the intermediate race (Kazakhs and Turkmens)
Locus | Genotype | N.O, % | N.E, % | χ2 d.f. = 1 | Allele frequency | Ho He | D |
С677T | CC | 66.0 | 65.6 | 0.0131 p=0.984 | C=0.810 T=0.190 | Ho=0.300 He=0.308 | 0.026 |
CT | 30.0 | 30.8 | |||||
TT | 4.0 | 3.6 | |||||
A1298C | AA | 40.0 | 39.6 | 0.0011 p=0.996 | А=0.630 С=0.370 | Ho=0.460 He=0.466 | 0.013 |
AC | 46.0 | 46.6 | |||||
CC | 14.0 | 13.6 | |||||
A2756G | AA | 40.0 | 48.8 | 0.258 p=0.294 | А=0.670 G=0.330 | Ho=0.540 He=0.442 | -0.22 |
AG | 54.0 | 42.1 | |||||
GG | 6.0 | 9.1 | |||||
A66G | AA | 26.0 | 23.0 | 0.0438 p=0.704 | А=0.480 G=0.520 | Ho=0.440 He=0.499 | 0.12 |
AG | 44.0 | 50.0 | |||||
GG | 30.0 | 27.0 |
N.O. is the observed frequency of genotypes; N.E. is the expected frequency of genotypes; the χ2 criterion is used to assess whether the observed genotype distribution corresponds to the expected one based on the Hardy-Weinberg equilibrium; d.f. is the number of degrees of freedom; Ho and He are the observed heterozygosity and expected heterozygosity, respectively; D is the relative deviation of the observed heterozygosity from the expected one (Selender’s coefficient)