Polymorphism of Folate Cycle Genes (MTHFR, MTR and MTRR) in Vegetable Farm Workers of Different Ethnicities
Table 1 - Comparative analysis of genotype frequencies in polymorphic variants of folate cycle genes in the Caucasian race (Russians)
Locus | Genotype | N.O, % | N.E, % | χ2 d.f. = 1 | Allele frequency | Ho He | D |
С677T | CC | 45.8 | 44.4 | 0.0222 p=0.911 | C=0.667 T=0.333 | Ho=0.417 He=0.444 | -0.061 |
CT | 31.0 | 31.0 | |||||
TT | 3.5 | 3.5 | |||||
A1298C | AA | 56.2 | 59.4 | 0.394 p=0.462 | А=0.771 С=0.229 | Ho=0.417 He=0.353 | 0.18 |
AC | 41.7 | 35.4 | |||||
CC | 2.1 | 5.2 | |||||
A2756G | AA | 45.8 | 48.8 | 0.124 p=0.640 | А=0.698 G=0.302 | Ho=0.479 He=0.422 | 0.14 |
AG | 47.9 | 42.1 | |||||
GG | 6.3 | 9.1 | |||||
A66G | AA | 16.6 | 18.3 | 0.0149 p=0.906 | А=0.427 G=0.573 | Ho=0.521 He=0.489 | 0.065 |
AG | 44.8 | 49.7 | |||||
GG | 24.2 | 21.7 |
N.O. is the observed frequency of genotypes; N.E. is the expected frequency of genotypes; the χ2 criterion is used to assess whether the observed genotype distribution corresponds to the expected one based on the Hardy-Weinberg equilibrium; d.f. is the number of degrees of freedom; Ho and He are the observed heterozygosity and the expected heterozygosity, respectively; D is the relative deviation of the observed heterozygosity from the expected one (Selender’s coefficient)