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The article presents the data of studying the effect of adding antibiotics and vitamin-mineral supplements to the nutrient medium on the number of colonies of the Saccharomyces cerevisiae strain of cattle feed additive for Livicell SC Titan Plus. The studies were carried out at the Department of Biotechnology and Microbiology of the National Research University "BelSU" in 2019. Yeast contained in the feed additive was sown on Saburo agar with the addition of chloramphenicol. A phosphate buffer solution was used to dissolve the samples. Preparing a series of subsequent dilutions of 1: 100; 1: 1000 ... 1: 109. Crops with crops were incubated for 72 hours at a temperature of 30 С. Antibiotics and vitamin-mineral supplements were added to the nutrient medium in the concentrations recommended by the manufacturer for use. Control served as agar Saburo. The growth of colonies of S. cerevisiae was inhibited by the antibiotics Enroflon, Pulmokit, Solamox, Sulteprim, Tilmozin (by 22%, 7%, 9%, 4% and 36%, respectively) and the vitamin-mineral supplement VitAmMin by 28%. An increase in CFU values of S. cerevisiae by more than 2 times with the addition of Productive Forte was noted. The antibiotics Soladoxy 500, Solamox, Sulteprim did not affect the number of colonies of S. cerevisiae. In the diet with a feed additive for cattle, Lewisel SC Titan Plus is recommended to appoint (if necessary) tetracyclines or Tilmipul macrolide, or amphenicol Florfenicol, or fluoroquinolone Kvinocyclinum.
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